Multiplex stress resistance in cells from long-lived dwarf mice.
نویسندگان
چکیده
Mutations that extend nematode longevity by interference with IGF-I/insulin sensing pathways also lead to resistance to multiple forms of stress. Here, we report that skin-derived fibroblasts from Snell dwarf mice, already known to show increased longevity and delayed aspects of aging, are resistant to multiple forms of cellular stress, including UV light, heat, paraquat, H2O2, and the toxic metal cadmium. The findings suggest that increases in cellular resistance to stress may mediate extended longevity in mammals.
منابع مشابه
Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress.
Previous studies have shown that dermal fibroblast cell lines derived from young adult mice of the long-lived Snell dwarf mutant stock are resistant, in vitro, to the cytotoxic effects of H(2)O(2), cadmium, UV light, paraquat, and heat. We show here that similar resistance profiles are seen in fibroblast cells derived from a related mutant, the Ames dwarf mouse, and that cells from growth hormo...
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عنوان ژورنال:
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology
دوره 17 11 شماره
صفحات -
تاریخ انتشار 2003